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Silica-Bound Scavengers

 

“Although we now have some excellent methods to effect the construction of target molecules with an ever increasing level of complexity, there is a need to find new, strategically important processes which are environmentally cleaner, more efficient and which lead to greater structural variation in a shorter period of time”

S. V. Ley et al., J. Chem. Soc., Perkin Trans. 1, 2000, 3815

 

What is special about solid-supported scavengers?

Silica-bound scavengers are a class of insoluble solids that are used in synthetic chemistry to capture excess reagents, catalysts, metal complexes and some by-products. The use of insoluble scavengers expedites synthesis and increases lab productivity as follows:

 

  • Reagents and by-products can be trapped and separated by a simple filtration
  • Purification protocols including chromatography and liquid-liquid extractions, which are time consuming and difficult to scale up, are not required in some cases
  • One-pot multiple step reactions are more feasible to conduct
  • They are suitable for use in flow-through applications and automated synthesis

 

For an overview on the advantages of functionalised silica gels over their polymer-supported equivalents please refer to our “silica-bound reagents”.

 

SiliaBond® scavengers for organic synthesis and purification

SiliCycle Inc. is a pioneer in the development of functionalised silica gels, gathered under the name SiliaBond®, for use in synthesis and purification. The backbone of all SiliaBond® products is stationary phase silica gel having particle size 40 – 63 µm and pore size 60 Å.

The following tables provide information on the SiliaBond® scavengers. All reagents and scavengers are available in Flash, SPE and 96 well plate format. Please contact us with your enquiry or to request a quote.

 

SiliaBond® Scavengers for Electrophiles

 

Manufacturer SiliCycle® Inc.
Availability from 10 g to 25 kg
Particle Size 40 - 63 µm (mesh 230 - 400)
Pore Size 60 Å
Specific surface area 500 m2/g

 


Function to be scavenged
Recommended SiliaBond® scavengers:
Name (Product Code)
Structure

Acid chlorides

SiliaBond® Amine*
(R52030B)

SiliaBond® Diamine*
(R49030B)

SiliaBond® Triamine*
(R48030B)
SiliaBond® DMAP
(R75530B)
SiliaBond® Piperazine
(R60030B)

Alkyl halides

SiliaBond® Thiol*
(R51030B)

Anhydrides

SiliaBond® Amine*
(R52030B)

Boronic acids

SiliaBond® Diol
(R35030B)

Carbonyl compounds

SiliaBond® Amine*
(R52030B)
SiliaBond® Tosyl
Hydrazine (R61030B)

Captures aldehydes in the presence of ketones (latter requires acid catalysis)

Chloroformates

SiliaBond® Amine*
(R52030B)

Epoxides

SiliaBond® Thiol*
(R51030B)

Isocyanates

SiliaBond® Amine*
(R52030B)

Sulfonyl chlorides

SiliaBond® Amine*
(R52030B)
SiliaBond® DMAP
(R75530B)
SiliaBond® Piperazine
(R60030B)

 

* These products are also versatile metal scavengers

 

SiliaBond Scavengers for Nucleophiles

 

Manufacturer SiliCycle® Inc.
Availability from 10 g to 25 kg
Particle Size 40 - 63 µm (mesh 230 - 400)
Pore Size 60 Å
Specific surface area 500 m2/g

 


Function to be scavenged
Recommended SiliaBond® scavengers:
Name (Product Code)
Structure

Acids (including acidic phenols)

SiliaBond® Amine*
(R52030B)
SiliaBond® Diamine*
(R49030B)
SiliaBond® Triamine*
(R48030B)
SiliaBond® Carbonate
(R66030B)

 

Scavenges 99% of phenylboronic acid (1 eq., after 1 h at room temperature)

SiliaBond® TBD*
(R68530B)

Scavenges 98% of phenylboronic acid (1 eq., after 1 h at room temperature)

Alcohols

SiliaBond® Tosyl

Chloride (R44030B)

Alkoxides

SiliaBond® Isocyanate
(R50030B)
SiliaBond® Carboxylic
Acid (R70030B)

SiliaBond® Tosyl

Chloride (R44030B)

Amines (primary and secondary)

SiliaBond® Isocyanate
(R50030B)
SiliaBond® Propylsulfonic
Acid (R51230B)
SiliaBond® Succinic
Anhydride (R64530B)

Offers selection over alcohols

SiliaBond® Tosic

Acid (R60530B)

SiliaBond® Tosyl

Chloride (R44030B)

Amines (tertiary)

SiliaBond® Tosic

Acid (R60530B)

Anilines

SiliaBond® Succinic
Anhydride (R64530B)

SiliaBond® Tosyl

Chloride (R44030B)

Borohydrides

SiliaBond® Tosic

Acid (R60530B)

Hydrazines

SiliaBond® Isocyanate
(R50030B)

SiliaBond® Tosyl

Chloride (R44030B)

Organometallic Reagents

SiliaBond® Carboxylic
Acid (R70030B)

SiliaBond® Tosyl

Chloride (R44030B)

Thiols

SiliaBond® Isocyanate
(R50030B)
SiliaBond® Maleimide
(R71030B)

Immobilises peptides and proteins

Thiolates 

SiliaBond® Isocyanate
(R50030B)

 

* These products are also versatile metal scavengers

 

SiliaBond® Metal Scavengers

 

Manufacturer SiliCycle® Inc.
Availability from 10 g to 25 kg
Particle Size 40 - 63 µm (mesh 230 - 400)
Pore Size 60 Å
Specific surface area 500 m2/g

 


SiliaBond® scavenger

Metal to be scavenged:
Pd
(II)
Pd
(0)
Sn
Zn
Pb
Ni
(II)
Ni
(0)
Cu
Co
Rh
(III)
Ru
Cd
Hg
(II)
Fe
Cr
(III)
Amine (R52030B)
Diamine (R49030B)
Pyridine (R43030B)
TAAcOH (R69030B)
TAAcONa (R69230B)
TBD (R68530B)
Thiol (R51030B)
Thiourea (R69530B)
Triamine (R48030B)
••

 

  Preferred scavenger
  Scavenges
  Reported in the literature or by customers

 
   
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